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Sunday, April 21, 2024

Fully Funded PhD Position at INARE in France 2024| Control of Oocyte Reserve in Fish

Fully Funded PhD Position at INARE in France 2024| Control of Oocyte Reserve in Fish is open now. The French National Research Institute for Agriculture, Food, and Environment (INRAE), previously known as INRA (National Institute for Agricultural Research), is indeed a prominent research institution in France and internationally. INRAE conducts research in various fields related to agriculture, food, and the environment. Its research activities cover a wide range of topics, including agriculture, agroecology, animal and plant sciences, food safety, and environmental sustainability.

INRAE’s research encompasses a broad spectrum of topics, including crop breeding and improvement, sustainable agriculture practices, animal health and genetics, biodiversity conservation, and the study of ecosystems and their interactions with agriculture. The institute’s work is essential for advancing sustainable and environmentally responsible practices in agriculture and food production. It is now offering PhD position for Role of miRNAs in the Control of Oocyte Reserve in Fish. Applicants from all over the world can apply for this opportunity. Candidates must have Master or Engineering degree in relevant field.

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Fully Funded PhD Position at INARE in France 2024

Program: PhD Position

Coverage: Fully Funded

Nationality: International

Degree Level: PhD

Duration: 3 Years

Monthly Gross: 2044€

Required Education:

Masters or Engineering degree in reproductive and developmental biology, and in cellular and molecular biology.

Project Description

Research will be conducted in role of miRNAs in the Control of Oocyte Reserve in Fish. This thesis is part of a research project that seeks to uncover the basic workings of the egg supply in fish ovaries, which produce mature eggs during each reproductive cycle. This study aims to help us understand the natural changes in fish that are important for things like protecting wild fish populations and making fish farming better. This project will be co-supervised by Violette Thermes (LPGP, INRAE) and Frédérique Clément (MUSCA, INRIA).

The researcher will employ a variety of techniques in their work. These include 3D imaging through confocal microscopy, which will be conducted using the LPGP 3D imaging platform. They will harness open-source Deep Learning algorithms for image analysis to extract valuable insights from their data. Additionally, histology techniques such as in situ hybridization (utilizing RNAscope technology) and immunohistochemistry, involving antibodies or nanobodies, will be utilized to examine tissue samples. To delve into gene expression patterns, the researcher will turn to transcriptomics approaches, specifically RNA-seq. These techniques collectively form the toolkit for their research, enabling a comprehensive exploration of their objectives.

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Hypothesis of the Project

The current hypothesis is that, similar to mammals, the regulation of the egg supply in a female fish’s lifetime involves paracrine mechanisms mediated by factors like the anti-müllerian hormone (AMH). In our laboratory research, we have also identified two specific microRNAs that are crucial for maintaining a female fish’s ability to lay eggs in each reproductive cycle. Based on these findings, we propose that these two microRNAs, in addition to AMH, play key roles in managing the egg reserve and controlling the overall reproductive capacity of female fish.

Objective of Project

  • To understand the role of AMH and two miRNAs in forming and renewing the egg reserve in fish.
  • To conduct in vivo experiments in specially bred Medaka fish lines (including KO and transgenic) and create new fish lines using CRISPR/Cas9 technology.
  • To gain insights into the mechanisms behind this process with implications for preserving wild fish populations and improving fish farming practices.

Benefits of Fully Funded PhD Position at INARE in France 2024

  • Up to 30 Days of Annual Leave: Aspirants will have the opportunity to take up to 30 days of paid time off each year, in addition to 15 days of “Reduction of Working Time” for full-time employees.
  • Parenting Support: We offer assistance with childcare through CESU childcare services, as well as leisure services to support your family.
  • Holiday and Leisure Services: Enjoy the perks of holiday vouchers and access to accommodations at special rates for your leisure time.
  • Skills Development: We have programs in place for your professional growth, including training and career advice.
  • Sports and Cultural Activities: Engage in various sports and cultural activities to enrich your personal life.
  • Social Support: We provide guidance and a listening ear, as well as social assistance and loans when needed.
  • Benefit from collective catering options, ensuring you have access to quality meals.

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Eligibility Criteria of Fully Funded PhD Position at INARE in France 2024

  • All overseas students are eligible to apply.
  • Applicants must have Master or Engineering degree in reproductive and developmental biology, and in cellular and molecular biology. 
  • Applicants having experience and proficiency in microscopy and image analysis will be preferred.

How to Apply for Fully Funded PhD Position at INARE in France 2024

  • Applicants should apply online for these positions.
  • Candidates should send CV and motivation letter at following given email address.
  • All eligible candidates will be considered.
  • Application received after last date will not be entertained.

Deadline

  • Last date to apply for Fully Funded PhD Position at INARE in France is 30th November, 2023.

Email Address to Send CV and Motivation Letter

[email protected]

[email protected]

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